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Original Articles

Clinical Pain 2020; 19(1): 8-15

Published online June 30, 2020 https://doi.org/10.35827/cp.2020.19.1.8

Copyright © Korean Association of Pain Medicine.

Effects of Bone Marrow Aspirate Concentrate-Platelet-rich Plasma Versus Hyaluronic Acid on Patients with Knee Osteoarthritis: A Randomized Controlled Trial

골수 흡인-혈소판 풍부 혈장과 히알루론산의 관절강내 주사의 효과 비교

Byung Chan Lee, M.D.1, Ah Ran Kim, M.D.1, Eun Kyung Kim, M.S.2, Sun Jeong Kim, M.S.3 and Sang Jun Kim, M.D., Ph.D.4

이병찬1ㆍ김아란1ㆍ김은경2ㆍ김선정3ㆍ김상준4

1Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 3R&D Center, ENCell Co. Ltd, 4Seoul Jun Rehabilitation Clinic, Seoul, Korea

성균관대학교 의과대학 삼성서울병원 재활의학교실1, 가톨릭대학교 의과대학 내과학교실 내분비내과2, 이엔셀 바이오, R&D 센터3, 서울준재활의학과4

Received: March 20, 2020; Accepted: June 5, 2020

Abstract

Objective: To compare the therapeutic efficacy of the bone marrow aspirate concentrate (BMAC)- platelet-rich plasma (PRP) complex with hyaluronic acid in patients with knee osteoarthritis. Method: Thirty-four patients with knee osteoarthritis participated in this study. Seventeen patients in the study group underwent BMAC and PRP extraction followed by intra-articular injection of BMAC-PRP complex within affected knee. Seventeen patients in the control group underwent intra-articular injection of hyaluronic acid. Knee injury, osteoarthritic outcome score (KOOS), and EuroQol-5D (EQ-5D) questionnaire were evaluated before, one month, three months, and six months after the injection. Results: There were statistically significant temporal differences in total KOOS scores in both BMAC-PRP and HA groups. However, there were no significant group difference in the study period. In the Sports and Recreational Function Scale, there was statistically significant improvement in the BMAC-PRP group compared to the HA group at three months (p=0.041). There were no side effects or complications in both groups. Conclusion: Intra-articular injection of BMAC-PRP showed better functional recovery in the OA at three months and this can be an alternative treatment in terms of functional recovery in the OA in addition to the decrease of pain.

KeywordsBone marrow aspiration concentrates, Platelet rich plasma, Hyaluronic acid, Osteoarthritis, Knee

Korean Association of Pain Medicine

Vol.22 No.2
December 2023

eISSN: 2765-5156

Frequency: Semi Annual

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